Cisplatin mitochondria
WebJul 5, 2024 · Mitophagy is an autophagic procedure that specifically clears damaged mitochondria and maintains its homeostasis. Emerging evidence indicates that mitophagy is involved in many physiological processes, including cellular homeostasis, cellular differentiation and nerve protection. Web2 days ago · Complex 37 and, above all, 38, were the most effective, but the latter led to higher activated Pt content inside the cells (probably because of its greater reduction rate), as well as inside the mitochondria, compared with complex 37 and cisplatin. To explore the mitochondrial effect caused by complexes 37 and 38, the level of mitochondria ...
Cisplatin mitochondria
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WebMar 20, 2024 · Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in vitro. Astrocytes are key players in supporting … WebAug 30, 2024 · Both cisplatin and IFT88-KD caused primary cilia shortening, downregulated mitochondrial oxidative phosphorylation capacity, and had defective fatty acid oxidation and decreased ATP production. Furthermore, IFT88 overexpression enhanced mitochondrial respiration, which partially counteracted cisplatin-induced defective fatty …
WebJul 10, 2024 · Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic … WebJun 10, 2024 · NUS chemists have developed a mitochondria-targeted fluorescent probe for real-time imaging of clinically important anticancer drug cisplatin in live cancer cell …
WebFunctional validation using SSBP1 knockdown demonstrated that the gene plays an important role in regulating mitochondrial mass. Depletion of SSBP1 increases the sensitivity of tumor cells to cisplatin-induced cell death, but only modestly impacts the ability of tumor cells to proliferate in the absence of the drug. WebJan 9, 2024 · Cancer Drug 49 Times More Potent than Cisplatin ... business news
WebMay 7, 2024 · Meanwhile, cisplatin causes nuclear and mitochondrial DNA damage, which activates peroxisome proliferator-activated receptor-γ coactivator-1α and increases transcription factor A (TFAM) expression. TFAM transposition to the mitochondria leads to mitochondrial biosynthesis and activation, thereby increasing mitochondrial ROS and …
WebKey results: We demonstrated that the prominent mitochondrial fragmentation occurred in experimental models of cisplatin-induced nephrotoxicity, which was coupled to radical oxygen species (ROS) overproduction, deterioration of mitochondrial function, release of apoptogenic factors and the consequent apoptosis. on the balance of probability uk lawWebNational Center for Biotechnology Information on the balance of probabilities 中文WebMay 10, 2024 · Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common … on the balance of probabilityon the balance sheet owner\\u0027s equity isWebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine monophosphate … on the balance of probabilities 意味WebOct 13, 2024 · Cisplatin also disrupts mitochondrial biogenesis, as indicated by reduced renal expression of the master regulator of mitochondrial biogenesis PPARG coactivator 1 alpha (PPARGC1A, also known... ionized drugs are drugs that contain aWebSep 30, 2024 · Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux, detoxification by intracellular GSH, and nucleotide excision repair machinery-mediated nuclear DNA repair. In this work, theranostic Pt(IV)-NPs, which are precisely self-assembled b … ionized compounds