Fbw7 nr4a1 scd1
WebMechanistically, we found FBW7 inhibited the expression of stearoyl-CoA desaturase (SCD1) via inhibiting nuclear receptor subfamily 4 group A member 1 (NR4A1). SCD1 … WebThe results revealed that FBW7 was negatively correlated with NR4A1 and SCD1 (Fig. 7C, and Fig. S5A). Both NR4A1 and SCD1 were high expression in pancreatic cancer …
Fbw7 nr4a1 scd1
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WebMar 6, 2024 · 在本文中，利用小鼠体外耐受性T (tolerance T)细胞诱导系统和全基因组表观和基因表达测序发现，耐受性T细胞与效应性T和Treg细胞具有显著差异。. 其中，NR4A1在耐受性T细胞中稳定性高表达。. NR4A1的过表达可以抑制效应细胞的功能，而delet 耐受性T细胞后，T细胞的 ... WebThe nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 gene.. Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. NR4A1 is involved in cell cycle mediation, …
WebJan 1, 2024 · SCD1 was reported to inhibit both ferroptosis and apoptosis, which was consistent with the function of FBW7 and NR4A1, another FBW7 down-regulated gene … WebFeb 21, 2024 · Mechanistically, we found FBW7 inhibited the expression of stearoyl-CoA desaturase (SCD1) via inhibiting nuclear receptor subfamily 4 group A member 1 (NR4A1). SCD1 was reported to inhibit both ...
WebFBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase. SCF(FBW7) degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cy … WebAtlanta news, sports, Atlanta weather, entertainment, business and political news from The Atlanta Journal Constitution - What's really going on in Atlanta
WebAug 1, 2024 · For the FBW7-NR4A1-SCD1 signaling pathway, the study confirmed that FBW7 strengthens the cytotoxic effect of gemcitabine on pancreatic cancer cells via activating ferroptosis, so it could be used as a new target for chemotherapy, reduce the resistance of chemotherapy drug therapy and provide a new strategy for clinical …
WebJan 1, 2024 · FBW7 is correlated with NR4A1 and SCD1 in pancreatic cancer tissues. (A, B) Representative tissue immunofluorescence and IHC staining of FBW7, NR4A1, SCD1 in … great neck south high schoolWebDownload scientific diagram FBW7 inhibits SCD1 transcription via NR4A1. (A) qRT-PCR detected NR4A1 and NR4A2 mRNA in FBW7 T205A or FBW7 R465H overexpressed PANC-1 and SW1990 cells. great neck south reunionWebAug 1, 2024 · FBW7(F-box and WD repeat domain-containing 7) exerts tumor-suppressive effects by targeting the degradation of oncoproteins. In pancreatic cancer cells, FBW7 inhibits the expression of SCD1 by inhibiting NR4A1(nuclear receptor subfamily 4 group A member 1), which induces ferroptosis to exert its anticancer activity [156] . floor and decor porcelain tilesWebNr4a1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions … great neck south middle school bell scheduleWebMechanistically, we found FBW7 inhibited the expression of stearoyl-CoA desaturase (SCD1) via inhibiting nuclear receptor subfamily 4 group A member 1 (NR4A1). SCD1 was reported to inhibit both ... great neck south middle school nyWebAug 16, 2024 · NR4A1 is an orphan nuclear receptor that belongs to nuclear subfamily 4 (NR4A) receptors. NR4A1 plays an important role in many malignant carcinomas, such as colorectal cancer, breast cancer, … floor and decor pro appWeb天上凡星. 这篇文章主要发现了肿瘤抑制蛋白、E3泛素蛋白连接酶FBW7受到诸如电离辐射、氧化物等应激压力时，会降解端粒保护蛋白TPP1，促使端粒暴露和缩短，引发干细胞老化或癌症，以及肺纤维化，而作者合成了一种拟肽类药物TELODIN可以保护端粒、防止端粒 ... floor and decor prefinished hardwood