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Aquaporin 4: a player in cerebral edema and neuroinflammation?

Aquaporin 4: a player in cerebral edema and neuroinflammation?

WebMay 5, 2024 · Astrocyte migration depends on AQP4 at the leading edge (Saadoun et al., 2005); inhibiting AQP4 relocalization may reduce the number of infiltrating reactive astrocytes. An additional benefit of inhibiting AQP4 relocalization may therefore be a reduction in the number of invading, reactive astrocytes and in the extent of glial scarring. Web1 day ago · Studies by Verkman and colleagues have implicated AQP4 in decreased astrocyte motility and proliferation (Auguste et al., 2007; Saadoun et al., 2005) processes that may contribute to the formation and clearance of Aβ plaques. A more recent study from this group demonstrated that Aqp4 gene ac lorenzo kai passed away WebMay 8, 2024 · Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer’s disease (AD) and other neurological conditions with prominent astrogliosis. AQP4 redistribution has been proposed to impair bulk Aβ clearance in AD, … WebAquaporin-4 (AQP4) is a water channel expressed in astrocytes throughout the central nervous system, as well as in epithelial cells in various peripheral organs. AQP4 is … ac lorenzo kai cause of death WebMar 31, 2024 · Aquaporin 4 (AQP4) is highly expressed on astrocytes and is critical for controlling brain water transport in neurological diseases. Tumor necrosis factor (TNF)-α … WebAQP4, the most abundant aquaporin in the CNS, is mainly located in the ependymal-glial-limiting membranes, including the processes of the subpial astrocytes in the cortex, the … ac lorenzo cause of death WebOct 27, 2016 · The water-permeable channel aquaporin-4 (AQP4) is highly expressed in perivascular astrocytes of the mammalian brain and represents the major conduit for water across the blood-brain barrier. Within these cells, AQP4 is found in great quantities at perivascular endfoot sites but is detected in lesser amounts at the membrane domains …

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