WebMar 1, 2024 · Most scientists previously believed that metformin works by inhibiting complex I, the first and largest of the mitochondrial complexes that creates the hydrogen ion gradient. However, Shulman’s group has previously demonstrated that metformin only inhibits complex I at much higher pharmacological concentrations than what is typically … WebSep 15, 2024 · The uses of Metformin are as follows: 1. Type 2 Diabetes Mellitus: Metformin is now established as a first-choice drug for all type 2 diabetes mellitus patients, except when not tolerated or contraindicated. The given dose is 0.5 to 2.5 g/day in 2-3 divided doses after food. It can be given as a monotherapy or combination with other oral ...
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