In class switch recombination
Webclass switch recombination CTCF CCCTC-Binding Factor DDX1 DEAD-box RNA helicase 1 DNA-PK DNA protein kinase DNA-PKcs DNA-dependent protein kinase catalytic subunit DSB double-strand breaks Ebf1 early B-cell factor 1 eEF1A eukaryotic elongation factor 1 α Erag enhancer region of RAG1/2 Exo1 exonuclease 1 FOXO Forkhead box G4 G-quadruplexes … WebJun 28, 2024 · Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies.
In class switch recombination
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WebFeb 10, 2014 · Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation (SHM) and class switch recombination (CSR), the genetic alterations that engrave antigen memory in the Ig gene locus (1, 2).Both events are dependent on transcription of the target loci and take place during the G1 phase of the cell cycle ().AID … WebApr 30, 2015 · This video describes two processes that occur during B-cell differentiation in the germinal center: Somatic hypermutation and class switch recombination. Show more Show more Somatic hypermutation...
WebAug 20, 2024 · Class-switch recombination (CSR) is an intrachromosomal DNA rearrangement of the immunoglobulin (Ig) heavy-chain locus. As a result, IgM-IgD mature … WebDec 14, 2012 · Class switch recombination is an irreversible process that can occur repeatedly until the immunoglobulin heavy chain repertoire is exhausted in a given cell. The regulation and execution of class switch recombination is dependent on the combined activity of protein complexes, chromosomal restructuring and DNA transcription [8].
WebMolecular Mechanisms of IgE Class Switch Recombination Pei Tong and Duane R. Wesemann Abstract Immunoglobulin (Ig) E is the most tightly regulated of all Ig heavy chain (IgH) isotypes and plays a key role in atopic disease. The gene encoding for IgH in mature B cells consists of a variable region exon—assembled from component gene WebAug 3, 2024 · Summary. Activation-induced cytidine deaminase (AID) initiates both class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. Mechanisms of AID targeting and catalysis remain elusive despite its critical immunological roles and off-target effects in tumorigenesis. Here, we produced active human AID and ...
WebBinding of LBP-1a to specific immunoglobulin switch regions in vivo correlates with specific repression of class switch recombination
WebImmunoglobulin heavy chain class switch recombination (CSR) requires targeted formation of DNA double-strand breaks (DSBs) in repetitive switch region elements followed by ligation between distal breaks. The introduction of DSBs is initiated by activation-induced cytidine deaminase (AID) and requires base excision repair (BER) and mismatch ... bingdailyquotes wednesdayWebAug 20, 2024 · Class-switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect … cytoplasmic translation是什么WebDec 21, 1998 · Antibody class switching is mediated by somatic recombination between switch regions of the immunoglobulin heavy chain gene locus. Targeting of recombination to particular switch regions is strictly regulated by cytokines through the induction of switch transcripts starting 5′ of the repetitive switch regions. However, switch transcription as … cytoplasmic transfer procedureWebTo enhance both the ability of immunoglobulins to recognize and bind to foreign antigens and the effector capacities of the expressed antibodies, naive B cells will undergo class … cytoplasmic translational initiationWebAID deficiency caused a complete defect in class switching and showed a hyper-IgM phenotype with enlarged germinal centers containing strongly activated B cells before or … cytoplasmic translation翻译WebOct 28, 2008 · Switch recombination depends on S region transcription, which produces stable RNA/DNA hybrids, identified at the S regions of activated B cells ( 25 ); and it is region-specific but not site-specific, reflecting in part the ability of AID to attack at many different sites within an S region. cytoplasmic transfer ivfWebJan 15, 2002 · The relationship between class switch recombination (CSR) and somatic hypermutation has been unclear. By using human CD27 − naive B cells, we investigated the somatic hypermutation and producibility of immunoglobulins (Igs) that occur after CSR. bing daily screensaver